Tirzepatide Dosage Chart: How Titration Works
A plain explanation of the tirzepatide dosage schedule, why titration is gradual, and how a physician adjusts your dose to balance results and side effects.
Published June 11, 2026 · 2 min read
The short answer
Tirzepatide is titrated gradually, typically starting at 2.5 mg once weekly and stepping up about every four weeks (2.5, 5, 7.5, 10, 12.5, up to 15 mg) as tolerated. The schedule is a guide, not a race: a physician adjusts the pace to your response and side effects.
The standard titration schedule
The typical tirzepatide schedule begins at 2.5 mg once weekly for four weeks, which is a starting dose meant to ease your body in, not a treatment dose. From there it commonly increases to 5 mg, then in 2.5 mg steps roughly every four weeks toward a maintenance dose, up to a maximum of 15 mg weekly.
Not everyone needs the maximum. Many people do well at a middle dose, and the goal is the lowest dose that gives a good result with manageable side effects.
Why supervision beats following a chart alone
A chart cannot see how you respond. Move up too fast and you invite nausea and other side effects; move up only when ready and the experience is far smoother.
In a supervised program, your physician decides each step based on your weight trend, side effects, and labs, and will hold or slow the schedule when that is the right call. That judgment is the difference between a chart and care.